Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00911-3 If general cancer treatment fails, a tumour-type-specific therapy might be tried for other cancers with genetic changes in the targeted pathway. How well does this work?
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How effective is the personalized off-label use of targeted cancer treatment?
Giant cancer study reveals effectiveness of ‘off label’ treatments
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01241-0 Genomics-guided trial could increase options for people undergoing cancer therapy — plus, a landmark ancient-genome study reveals natural selection in hundreds of human genes.
Prospective evaluation of genomics-guided off-label treatment
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10405-x Evaluation by the Drug Rediscovery Protocol of off-label use of 37 approved cancer drugs on 1,610 patients showed modest activities overall, although subgroups of responders suggest that off-label drug use could be beneficial in tandem with more stringent biomarker selection.
Four rising stars shaping the future of cancer research
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00688-5 Meet the creative minds that aim to improve cancer detection and treatment.
A mechanism for adaptive genome regulation in cancer
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10269-1 In this Perspective article, a theoretical framework for how the AP-1 family of transcription factors mediates cellular adaptation in cancer drug resistance is proposed.
