Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10269-1 In this Perspective article, a theoretical framework for how the AP-1 family of transcription factors mediates cellular adaptation in cancer drug resistance is proposed.
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A mechanism for adaptive genome regulation in cancer
Giant cancer study reveals effectiveness of ‘off label’ treatments
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01241-0 Genomics-guided trial could increase options for people undergoing cancer therapy — plus, a landmark ancient-genome study reveals natural selection in hundreds of human genes.
Mapping convergent regulators of melanoma drug resistance by PerturbFate
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10367-0 PerturbFate is a high-throughput, cost-effective, single-cell platform that systematically profiles CRISPR interference perturbations to reveal common regulatory nodes and convergent phenotypic states across diverse genetic alterations linked to vemurafenib resistance in melanoma cells.
Molecular profiling of gene-edited cells reveals shared drug-resistance mechanisms
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01181-9 A platform for tracking the changes in gene expression and chromatin accessibility that follow interference with specific genes has been developed. The platform, called PerturbFate, was applied to skin-cancer cells and showed that different genetic perturbations associated with tumour resistance push cells into a shared dedifferentiated state.
Tumour promotion through the lens of evolution
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10386-x This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable environmental and endogenous factors to expand tumorigenic clones.
