Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10405-x Evaluation by the Drug Rediscovery Protocol of off-label use of 37 approved cancer drugs on 1,610 patients showed modest activities overall, although subgroups of responders suggest that off-label drug use could be beneficial in tandem with more stringent biomarker selection.
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Prospective evaluation of genomics-guided off-label treatment
Giant cancer study reveals effectiveness of ‘off label’ treatments
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01241-0 Genomics-guided trial could increase options for people undergoing cancer therapy — plus, a landmark ancient-genome study reveals natural selection in hundreds of human genes.
How effective is the personalized off-label use of targeted cancer treatment?
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00911-3 If general cancer treatment fails, a tumour-type-specific therapy might be tried for other cancers with genetic changes in the targeted pathway. How well does this work?
Four rising stars shaping the future of cancer research
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00688-5 Meet the creative minds that aim to improve cancer detection and treatment.
Molecular profiling of gene-edited cells reveals shared drug-resistance mechanisms
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01181-9 A platform for tracking the changes in gene expression and chromatin accessibility that follow interference with specific genes has been developed. The platform, called PerturbFate, was applied to skin-cancer cells and showed that different genetic perturbations associated with tumour resistance push cells into a shared dedifferentiated state.
