Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10386-x This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable environmental and endogenous factors to expand tumorigenic clones.
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Tumour promotion through the lens of evolution
Editorial Expression of Concern: Creation of human tumour cells with defined genetic elements
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10504-9 Editorial Expression of Concern: Creation of human tumour cells with defined genetic elements
Giant cancer study reveals effectiveness of ‘off label’ treatments
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01241-0 Genomics-guided trial could increase options for people undergoing cancer therapy — plus, a landmark ancient-genome study reveals natural selection in hundreds of human genes.
Four rising stars shaping the future of cancer research
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00688-5 Meet the creative minds that aim to improve cancer detection and treatment.
A mechanism for adaptive genome regulation in cancer
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10269-1 In this Perspective article, a theoretical framework for how the AP-1 family of transcription factors mediates cellular adaptation in cancer drug resistance is proposed.
