Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10504-9 Editorial Expression of Concern: Creation of human tumour cells with defined genetic elements
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Editorial Expression of Concern: Creation of human tumour cells with defined genetic elements
Tumour promotion through the lens of evolution
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10386-x This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable environmental and endogenous factors to expand tumorigenic clones.
Molecular profiling of gene-edited cells reveals shared drug-resistance mechanisms
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01181-9 A platform for tracking the changes in gene expression and chromatin accessibility that follow interference with specific genes has been developed. The platform, called PerturbFate, was applied to skin-cancer cells and showed that different genetic perturbations associated with tumour resistance push cells into a shared dedifferentiated state.
Giant cancer study reveals effectiveness of ‘off label’ treatments
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01241-0 Genomics-guided trial could increase options for people undergoing cancer therapy — plus, a landmark ancient-genome study reveals natural selection in hundreds of human genes.
Four rising stars shaping the future of cancer research
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00688-5 Meet the creative minds that aim to improve cancer detection and treatment.
