Linear RAG scanning mediates editing of Igκ variable region repertoires
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10362-5 Studies explaining the secondary Igk recombination mechanism are described and Cer/Sis deletion and/or displacement is implicated as a developmental switch converting the rearrangement mechanisms from two-loop-based diffusional primary Igk into one-loop-based linear scanning secondary mechanisms.
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Linear RAG scanning mediates editing of Igκ variable region repertoires
